2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

PDF 2.47 MB

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2418):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-171575
    3'-Amino-2',3'-dideoxy-ATP
    3'-Amino-2',3'-dideoxy-ATP is a modified nucleotide. 3'-Amino-2',3'-dideoxy-ATP can serve as a potent chain terminator for various DNA sequencing methods, including radioactive and fluorescent sequencing, and is compatible with multiple sequencing enzymes.
    3'-Amino-2',3'-dideoxy-ATP
  • HY-134314
    8-Nitro-cGMP
    8-Nitro-cGMP is an electrophilic second messenger of redox signaling that can form a protein-S-cGMP adduct in s-guanylation process. 8-Nitro-cGMP is an autophagy inducer. 8-Nitro-cGMP promotes RANKL-induced osteoclast differentiation from macrophages. 8-Nitro-cGMP has vasodilator effect, and ameliorates the vascular endothelial dysfunction in diabetic mice.
    8-Nitro-cGMP
  • HY-B0182R
    Carmofur (Standard)
    		Inhibitor
    Carmofur (Standard) is the analytical standard of Carmofur. This product is intended for research and analytical applications. Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC50 of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI).
    Carmofur (Standard)
  • HY-W393450A
    dCDP disodium
    dCDP (2'-Deoxycytidine-5'-diphosphate) disodium is a monomeric raw material that can be used for nucleic acid synthesis.
    dCDP disodium
  • HY-157091
    Uridine, 5'-P,P',P'',P''-tetrahydrogen imidotriphosphate
    Uridine, 5'-(P,P',P'',P''-tetrahydrogen imidotriphosphate) is a non-hydrolyzable nucleotide that can synthesize RNA oligonucleotides.
    Uridine, 5'-P,P',P'',P''-tetrahydrogen imidotriphosphate
  • HY-178634
    2',5'-di-OBz-rC(Bz)
    2',5'-di-OBz-rC(Bz) is a monomeric raw material that can be used for nucleic acid synthesis.
    2',5'-di-OBz-rC(Bz)
  • HY-171523
    LNA-GMP
    LNA-GMP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    LNA-GMP
  • HY-137668
    2'-Deoxy-3',5'-ADP
    2'-Deoxy-3',5'-ADP (pdAp) is a monomeric raw material that can be used for nucleic acid synthesis.
    2'-Deoxy-3',5'-ADP
  • HY-178595
    DMTr-2'-O-Me-rA(Bz)-3'-(L)-PSM-phosphoramidite
    DMTr-2'-O-Me-rA(Bz)-3'-(L)-PSM-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-Me-rA(Bz)-3'-(L)-PSM-phosphoramidite
  • HY-W377455
    2',5-Difluoro-2'-deoxy-1-arabinosyluracil
    		98.88%
    5-Fluoro-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (2',5-difluoro-2'-deoxy-1-arabinosyluracil) is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    2',5-Difluoro-2'-deoxy-1-arabinosyluracil
  • HY-131799A
    3'-Amino-3'-deoxyadenosine-5'-O-diphosphate sodium
    3'-Amino-3'-deoxyadenosine-5'-O-diphosphate sodium is an amine-modified nucleotide that can be used in the synthesis of other active compounds. The coumarin-labeled derivatives of 3'-Amino-3'-deoxyadenosine-5'-O-diphosphate sodium exhibit significant fluorescence changes when interacting with myosin and can mimic the function of natural ADP.
    3'-Amino-3'-deoxyadenosine-5'-O-diphosphate sodium
  • HY-W1119943
    2'-OMe-8-Me-DMF-G Phosphoramidite
    2'-OMe-8-Me-DMF-G Phosphoramidite is a phosphoramidite compound containing modified guanine (G) and a dimethoxytrityl (DMT) group. 2'-OMe-8-Me-DMF-G Phosphoramidite can be used in RNA oligonucleotide synthesis.
    2'-OMe-8-Me-DMF-G Phosphoramidite
  • HY-177200
    DMT-biotinylated phosphoramidite
    DMT-biotinylated phosphoramidite is a phosphonamide acid that can be used in nucleic acid synthesis.
    DMT-biotinylated phosphoramidite
  • HY-W011793R
    4-Thiouridine (Standard)
    4-Thiouridine is a ribonucleoside analog, it is widely used in RNA analysis and (m)RNA labeling. 4-Thiouridine inhibits rRNA synthesis and causes a nucleolar stress response.
    4-Thiouridine (Standard)
  • HY-178537
    6'-O-DMTr-2'-O-Me-5'-Homo-U-3'-CE-phosphoramidite
    6'-O-DMTr-2'-O-Me-5'-Homo-U-3'-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    6'-O-DMTr-2'-O-Me-5'-Homo-U-3'-CE-phosphoramidite
  • HY-D1686C
    Biotin-16-aminoallyluridine-5'-triphosphate
    Biotin-16-Aminoallyluridine-5'-Triphosphate is a monomeric raw material that can be used for nucleic acid synthesis.
    Biotin-16-aminoallyluridine-5'-triphosphate
  • HY-138615A
    Deoxythymidine-5'-triphosphate sodium hydrate
    Deoxythymidine-5'-triphosphate (dTTP) sodium hydrate is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate trisodium salt is used in the synthesis of DNA.
    Deoxythymidine-5'-triphosphate sodium hydrate
  • HY-178535
    3'-ONH2-dTTP
    3'-ONH2-dTTP is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-ONH2-dTTP
  • HY-171514
    2'-F-CMP
    2'-F-CMP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2'-F-CMP
  • HY-164281
    5-Hydroxyisourate
    5-Hydroxyisourate is an oxidation product of Uric acid (HY-B2130), which can be catalyzed by 5-hydroxyisourate hydrolase to be converted into 2-oxo-4-hydroxy4-carboxy-5-ureidoimidazoline.
    5-Hydroxyisourate